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[9] The original N-terminally modified variants of this type, including LR3IGF-I and the related des(1-3)IGF-I, were shown to be consistently several-fold more potent than native IGF-1 in animal tissue-growth assays, a difference attributed directly to their reduced interaction with binding proteins

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[DOI] [PubMed] [Google Scholar] 11.Perier C., Bove J., Vila M., Przedborski S
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Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84

Link (Liebert Pub)
