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This process involves starting with a lower dose and gradually increasing it over several weeks or months until the target therapeutic dose is reached

Evergreening works because each listed patent forces an ANDA applicant to certify against it

Such trials are necessary to determine whether the promise shown in preclinical research translates to meaningful human benefit and to establish safe, effective dosing protocols

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most evidence is preclinical and from Russian research

The Orange Book identifies listed patents, their expiration dates, and patent use codes