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This paper presents an interesting study describing defective hepatic thyroid hormone signalling in human NAFLD

Since LCFAs preferentially undergo FAO in mitochondria, alterations in LCA levels may reflect changes in mitochondrial FAO in E4s with age compared to E2 and E3 mice

C., Sardi, J

En casos de hipotiroidismo, este mecanismo es especialmente relevante, ya que las clulas suelen no interpretar correctamente las seales hormonales, lo que ralentiza el metabolismo y provoca una cada en los niveles de energa