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One study did demonstrate that the multivitamin used for treatment resulted in improvements in biomarkers of energy metabolism (as well as oxidative stress) suggesting that the effect of the multivitamin may have been at least partially related to improvements in mitochondrial function ( in vitro assessment of compounds that may improve mitochondrial function in individuals with ASD ( Folate metabolism Several lines of evidence point to abnormalities in folate metabolism in ASD

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Toxicol Pathol 25, 5360

Many studies suggest that vitamin B12 is essential to developing the fetuss brain and nervous system