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They hinder reliable efficacy and safety assessments and limit broader clinical adoption compared to conventional drugs

The stronger the acid, the weaker the conjugate base

In vitro studies in prostate cancer cells with PROTAC UBX-390 (DC 50 = 2.4 nM, D max = 96%) demonstrated that it has a prolonged degradation activity superior to that obtained with predecessor PROTACs, such as ARV-110 (DC 50 = 3.1 nM, D max = 96%) which is currently in clinical studies

doi: 10.3390/pathophysiology30010006

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The changes in median methylmalonic acid (MMA) and total homocysteine (tHcy) levels over time are shown