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The mechanism may be related to inhibiting ATG16L1-mediated autophagy of normal colon epithelial cells, promoting ROS accumulation and NLRP3 inflammasome assembly

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Clinical Signs of Feline Hyperthyroidism Hyperactivity / Hyperexcitability Weight loss Increased appetite Vomiting / diarrhea Increased thirst Increased urination Hair loss Excessive appetite Increased heart rate Shortness of breath Seborrhea Chronic skin infections Cats with symptoms of feline hyperthyroidism may also experience secondary problems such as mild liver, kidney, or heart disease

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TMAO forms in the liver via the oxidation of trimethylamine (TMA), a product of the gut microbial metabolism of nutrients such as choline, L-carnitine, and phosphatidylcholine, which are abundant in red meat and other animal products