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In addition, some polyphenols can enhance the anti-tumour effect while antagonizing ototoxicity.Although polyphenols show good application prospects in the prevention and treatment of cisplatin ototoxicity, there are still some problems that need to be solved, such as the low bioavailability of polyphenols, the mechanism of action has not yet been fully elucidated, the optimal dosing regimen has not yet been determined, whether there is any superimposed effect of combining the various types of polyphenols, and whether the oral polyphenols can exert an otoprotective effect through the regulation of the intestinal flora through the intestinal-auricular axis.This study provides new insights into polyphenols as potential drug candidates for CIO by summarising the cytotoxic mechanisms of cisplatin and the mechanism of action of polyphenols targeting these mechanisms in order to retard the progression of CIO

10.2174/092986712799462630 Curr

The concentration of IL-1 and IL8 were measured quantitatively using ELISA kits in accordance with the manufacturers instructions

In 2010, Koo et al conducted a study on the biodegradation of branched PEI for gene delivery

Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam

Recent reports have also shown that Vit-C administration inhibits metastasis, tumor development, and inflammatory-associated cytokine production, while improving tumor inclusion and enhancing chemotherapy [34,35]