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In trying to identify the antigen exposed on aged RBC Kay carried out affinity purification of RBC proteins on immobilized IgG from senescent RBC and reported that this IgG NAb binds to a 62 kDa protein of old RBC (Kay, 1981)

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this has obvious clinical implications

10.3389/fphys.2021.673145 142 YamamotoM.KenslerT

Homocysteine induces 3-hydroxy-3-methylglutaryl coenzyme a reductase in vascular endothelial cells: A mechanism for development of atherosclerosis
