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Another meta-analysis also showed that prolonged treatment with higher doses of NAC (1200 mg/day) prevents exacerbations of COPD, while lower doses (600 mg/day) may be effective only for patients with chronic bronchitis, without COPD and without airway obstruction [57]

199 But for COPD patients without pulmonary hypertension, bosentan will aggravate their hypoxaemia

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