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Meta-analyses demonstrate improvements in LVEF and New York Heart Association (NYHA) class, although low bioavailability limits clinical impact, emphasizing the need for optimized formulations or combination strategies (Table 1)

Compliance requires alignment with local cosmetic regulations, ingredient listings, and claim substantiation requirements

Induction of autophagy by depolarization of mitochondria

Favism, neonatal jaundice and other manifestations of G6PD deficiency are outside the scope of this review

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Moberley SA, Holden J, Tatham DP, Andrews RM