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10.1016/j.jcis.2023.05.114 139 ZhenX.LiL.JiaL.ZhuA.YangY.WangS.et al (2023a)

Among them, caspase-3 is closely related to apoptosis and is activated by both intrinsic and extrinsic pathways, making it a focus for cancer therapy ( In addition to the above mentioned, small molecule prodrugs that can be activated by other kinds of enzymes have also been developed (Zhang H

The study showed that daily supplementation increased reduced glutathione levels in blood and tissues while reducing markers of oxidative stress, including malondialdehyde and protein carbonyl groups

This effect, while not a main research outcome, can be noticeable and may affect body weight measurements

As itaconate has anti-microbial and anti-inflammatory properties, this substance is considered as potential therapeutic drug for the treatment of inflammation in various diseases including traumatic brain injury and stroke