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Newborn Wistar rats (males only in the experimental phase were included) were separated from the dam for 3 h/day from postnatal day 19, and subsequently treated orally with quercetin or QNP at 10 or 40 mg/kg/day for 21 days starting at Post Natal Day (PND)

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However, the increase in molar ratio is entirely explained by the fact that IGF-I and IGFBP-3 increase with the same number of moles per liter, but with a larger relative increase in IGF-I than IGFBP-3 and with IGF-II molar concentrations being unchanged (112)