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757 The similarity in energy metabolism demands between tumor and immune cells results in competition for essential energy substrates

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They utilize the key histidine located next to the FMN for nucleophilic attack of the hydrogen atom on the substrate and thereby initiates the catalytic reaction, and NAD(P)H cofactor to provide electrons to achieve the subsequent reductase activity 19,20,21

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Our previous study identified glutamine metabolism (glutaminolysis)-related genes as key determinants of sulfasalazine sensitivity in CD44-positive CSCs, 69 highlighting their potential as markers for the efficacy of ferroptosis-inducing therapies

doi:10.1038/tp.2012.35 Hirschfeld RM, Williams JB, Spitzer RL, Calabrese JR, Flynn L, Keck PE Jr, Lewis L, McElroy SL, Post RM, Rapport DJ, Russell JM, Sachs GS, Zajecka J (2000) Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire