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Beyond the ENS, this transcriptional factor when selectively activated by the microbial metabolite indole produced by tryptophanase-expressing gut microbes interestingly induces neurogenic effects in the adult murine hippocampus as identified by elevated expression of -catenin, Neurog2, and VEGF- (Wei et al., 2021)
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Dimet-Wiley, A
RajagopalanSMohlerERIIILedermanRJMendelsohnFOSaucedoJFGoldmanCKet al

This binding may signal and trigger numerous pathways in organisms related to protein synthesis and adipose tissue reduction

What was striking about the T-cell response in the HCWs with abortive infection was the enrichment for T cells targeting the conserved nonstructural proteins of open reading frame 1ab (ORF1ab), which make up the core of the RTC [67]
