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Mechanistically, PKM2 lactylation alters its conformation to a preferential tetrameric over its otherwise dimeric/monomeric form, and thereby reduces PKM2 nuclear accumulation, where it would otherwise drive the expression of proglycolytic genes in interaction with HIF1 (Wang et al., 2022) as well as pro-inflammatory genes (Shirai et al., 2016)

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Moreover, cannabinoids hold potential in the treatment of neurological disorders such as epilepsy, multiple sclerosis, Parkinsons disease, and Alzheimers disease, offering neuroprotective and anti-inflammatory effects

Ilic S, Drmic D, Zarkovic K, Kolenc D, Coric M, Brcic L, et al
The MD simulation was performed using a 2 fs integration time step coupled with the SHAKE option

Glutathione is the expert maintenance crew, moving around and fixing the small bits of wear and tear that happen every day, keeping the machinery running perfectly
