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Meanwhile, 3-BP suppresses lactate production by inhibiting glycolysis, which not only repolarizes M2-type tumor-associated macrophages toward the M1 phenotypes and suppresses regulatory T cell (Treg) infiltration, but also alleviates cGAS lactylation to enhance cGAS activity and amplifying STING-mediated immune responses
The Keap1-Nrf2 pathway plays a central role in the protection of cells against oxidative and xenobiotic stresses
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Such situation can not only damage the growing plants but can also toxify the food chain, and endanger human life
2. Stier H, Vos E, Kenley D
