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In terms of mitochondrial dynamics, excessive androgens are responsible for the decreased mitochondrial fusion and increased fission-induced fragmentation, as evidenced by the marked increase in Drp1 gene expression in the liver of mice with PCOS (135)

doi: 10.1016/j.cell.2010.01.028 147 MartinetWDe MeyerGRAndriesLHermanAGKockxMM

Yeon JE, Choi KM, Baik SH, Kim KO, Lim HJ, Park KH, Kim JY, Park JJ, Kim JS, Bak YT, Byun KS, Lee CH: Reduced expression of peroxisome proliferator-activated receptor-a may have an important role in the development of non-alcoholic fatty liver disease

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