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These differences are determined by genetic factors and nongenetic variables such as age, sex, liver size, liver function, circadian rhythm, body temperature, and nutritional and environmental factors such as concomitant exposure to inducers or inhibitors of drug metabolism

For the first time, a large segment of the regenerative medicine community has attempted to meet the FDA on its own ground

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7 Translational and clinical implications The conceptual framework of redox endophenotypes holds significant translational potential for redefining IMI in clinical practice