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Histone lactylation-regulated METTL3 promotes ferroptosis via m6a-modification on ACSL4 in sepsis-associated lung injury

With an additional arginine at position 3, LR3 displays reduced binding to IGF binding proteins (IGFBPs), allowing researchers to study its direct effects on cell growth, repair, and metabolism

YA: Writing original draft, Investigation

The work was supported by grants from the Swiss National Science Foundation (31003A-113525), the European Union FP6 program on Hepatic and Adipose Tissue and Functions in the Metabolic Syndrome (EU-FP6 HEPADIP), and the FP7 program on European Drug Initiative on Channels and Transporters (EU-FP7 EDICT) to B

Lens transparency measurements Lens transparency was evaluated using an integrating sphere spectrophotometer (Lambda 950, PerkinElmer, USA) equipped with a customized fixture to secure rat lenses

Safety Profile: Preclinical studies suggest high specificity, but the potential for overkill in tissues where transient senescence is required for wound healing or tumor suppression remains a point of scholarly debate (Rabinovitch, 2023)