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In 1948, Rickes et al

This nano-gel can be rapidly cleaved in response to the highly-reductive conditions within MRSA-infected macrophages due to internal disulfide bonds linked with vancomycin antibiotics [14, 161,162,163,164]

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While this trial showed trends toward fat loss in the treatment groups, the primary endpoint of statistically significant weight reduction compared to placebo was not consistently achieved across all dose groups, and effect sizes were more modest than hoped

Analysis of glutathione mediated S -(de)nitrosylation in complex biological matrices by immuno-spin trapping and identification of two novel substrates