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10.1016/S0271-5317(05)80036-3 86 PawarR

Digestive Discomfort: This can include bloating, cramping, or a change in bowel movements

Evidence-Based Uses: Strong Scientific Support: Heavy metal poisoning treatment (multiple studies) Iron overload conditions (established therapy) Acute metal toxicity emergencies Moderate Evidence: Cardiovascular benefits in specific populations (TACT trial) Some anti-inflammatory effects Limited or No Evidence: Limited or No Evidence: Controversial Applications: Autism treatment (no proven benefit) General detoxification (not medically necessary) Anti-aging applications (insufficient evidence) According to Harvard Medical School, chelation therapy should only be used for proven medical indications with appropriate monitoring

Lora et al., 2005

Designation Structure Molecular weight (Da) Retention time (min) BPC157 1419.5 ~39.8 M1(Proline) 115.1 ~5.1 M2 1207.3 ~19.5 M3 1150.2 ~19.4 M4 1021.1 ~19.1 M5 1079.1 ~18.7 (Continued on following page) Frontiers in Pharmacology frontiersin.org09 He et al