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Nrf2 binds to antioxidant response elements (AREs) to enhance the expression of proteins essential for maintaining cellular redox balance [240, 241]

The different hGSTP1-1 mutants show slightly altered regioselectivities in the formation of the individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations [34]

Intrinsic disorders can be divided into abnormalities of the RBC membrane, metabolic enzymes, or hemoglobin

doi: 10.3389/fcell.2020.586578 49 JuJSongYNWangK

An increase in oxidative damage in the diabetic kidney may induce apoptosis and contribute to the development of diabetic nephropathy [312, 313, 315]

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