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Last Updated: July 5, 2026 Introduction to Pyruvate Metabolism and the TCA Cycle The bulk of the ATP used by all cells (except mature red blood cells), to maintain homeostasis, is produced by the re-oxidation of the reduced electron carriers, NADH and FADH 2 , within the mitochondrial oxidative phosphorylation pathway

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This work was supported by AMED Grant Number JP21zf0127001 (T.S.), JST, CREST Grant Number JPMJCR2123 (T.S.), MEXT KAKENHI Grant Number JP23H04946(T.S.) and World Premier International Research Center Initiative (WPI), Human Biology-Microbiome-Quantum Research Center (Bio2Q) (T.S.), MEXT, Japan