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Cognitive enhancement drugs have a difficult regulatory path because endpoints are subjective and trial design is challenging

It is difficult to judge for sure whether the early drastic decrease in Plp- and Mog- positive cells implies a drastic death/loss of the mature OLs or just an extreme-down regulation of the expression of these myelin-associated genes by the OLs while they themselves are still alive

Tracing Notochord-Derived Cells Using a Noto-Cre Mouse: Implications for Intervertebral Disc Development

Briefly, binary masks of Syt1 and Cntfr positive regions were obtained by applying a 1 sigma radius Gaussian blur filter and setting a user-defined threshold

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