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Vendor technical sheets and primary studies report selectivity over related methyltransferases and enzymes of the NAD salvage pathway [1,6,7]

No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children

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Obviously this ignores all those who require life long treatment due to other causes of B12 deficiency (of which there are many), thereby potentially causing great harm to the vast majority of their B12 deficient patients