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In a study of approximately 120 patients with cirrhosis and 5,000 healthy people in the PREVEND cohort study, severity of cirrhosis was found to be associated with high levels of betaine, a precursor of TMAO

Furthermore, noteworthy is that L-C exerts cardioprotective effects through alternative mechanisms, such as oxidative stress [35], nitric oxide [36], arterial hypertension, cardiac inflammation and fibrosis [3739], and interstitial remodeling [40], as well as by improving endothelial function [41]

Tissue Cell 49(3):410426

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Aleem A.A., Samad A.B., Slenker A.K

10.1161/circulationaha.111.075978 Circulation 48 HeathersG

[DOI] [PubMed] [Google Scholar] 85.Ellaway C.J., Peat J., Williams K., Leonard H., Christodoulou J