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However, a growing body of evidence reveals a pronounced immunoinflammatory phenotype in OA, wherein macrophages, T/B lymphocytes, and inflammatory factors such as IL-1, TNF-, and IL-6 play a critical role in the local microenvironment (105)

Which translates directly to a 10% dose error if you calculate injection volumes based on the assumed 5mg/ml rather than the actual 5.56mg/ml concentration

The study suggests that antidiabetic drugs might be linked to a delayed onset of PD (Pezzoli et al., 2023)