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Finally, MVP have been reported with increased prevalence in aneuploidies including Downs syndrome, WilliamsBeuren syndrome (Figure 1B), EhlersDanlos syndrome, osteogenesis imperfecta, pseudoxanthoma elasticum, Stickler syndrome, Larsen-like syndrome, fragile X syndrome, and polycystic kidney disease, but data regarding these associations remain less convincing ( Non-syndromic MVP Non-syndromic form of MVP is the most common condition of MVP