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Description

Mass spectrometry identity confirmation: Molecular weight must be verified via LC-MS to confirm the 16-amino acid sequence and the intramolecular disulfide bond, both critical structural features of this compound

This capacity of FcRn antagonists to modulate the pharmacokinetics of other IgG-based Ab therapeutics was investigated in a phase I clinical trial (NCT04973566) addressing the effect of nipocalimab on the pharmacokinetics of the IgG Fc-fusion etanercept, which consists of the extracellular domains of tumor necrosis factor-alpha receptor 2 fused to an IgG1 Fc

In Canada and most of the European Union, its not approved for medical or cosmetic use and is considered an unregulated compound (Health Canada advisory listing AOD9604 as unauthorized)

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