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Robinson et al., preprint, DOI: Interestingly, gravin was previously shown to play a role in 2 -AR desensitization, sequestration, and resensitization, as agonist stimulation of the 2 -AR increased interaction between the receptor-gravin complex and protein kinases A and C, GRK2, -Arr, and clathrin (Bagchi et al., 2018)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Ren Y., Sun-Waterhouse D., Ouyang F., Tan X., Li D., Xu L., Li B., Wang Y., Li F

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Chronic inflammation, immune exhaustion, and the presence of latent viral reservoirs in PWH make them less tolerant to cellular or genetic engineering interventions, increasing the risk of immune-related adverse events
