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Introducing an electron-withdrawing cyano group at the position of the Michael acceptor of ThiolQuant Green can accelerate reaction kinetics but simultaneously shift the K d value into the M range

[DOI] [PubMed] [Google Scholar] Small KM, McGraw DW, Liggett SB

During acute inflammation, TNF- is produced by macrophages which leads to a cascade of events that results in cell death via necrosis and apoptosis

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