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Concurrently, dynamic monitoring by leveraging liquid biopsies, multiomic profiling, and spatial transcriptomics will track realtime tumorimmune coevolution, reveal emergent resistance mechanisms, and guide early intervention before clinical progression occurs

These CD8 + T cells subsequently migrate to the tumor bed in a stem-like state, where they undergo further restimulation within the TME and develop a canonical effector program to unleash cytotoxicity upon encountering tumor cells [144]

Physiology 35, 302327

The second most common complaint in the first 24 hours is nausea, this is usually controlled with IV medications as well, most of the nausea is gone within 24 hours

histolytica , indicating the potential for additional targets

Recent large-scale single-cell transcriptomic atlases have already demonstrated the feasibility of systematically classifying glial cell diversity and revealed distinct astrocytes states across disease contexts 62,63,64