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3.1.4 Nrf2 pathway During IPF pathogenesis, persistent oxidative damage contributes to epithelial injury, fibroblast activation, and ECM deposition (Hybertson et al., 2011), while the Nrf2 signaling pathway plays a crucial role in mitigating oxidative stress

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It is designed to be inserted into the rectum where it dissolves or melts, releasing the glutathione for local absorption or to be carried into the systemic circulation

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