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CYP2E1 is located predominantly in the microsomal fraction of the cytosol, but is also expressed in mitochondria [148] and a three-fold increase in this enzyme was found in hepatic mitochondria isolated from ethanol-fed rats [149]

Combining the changes in the three groups, at the genus level, Clostridium_sensu_stricto_1 was increased in the TS group compared to the CON group, and GABA treatment alleviated the Clostridium_sensu_stricto_1 abnormality, suggesting a potential mechanism (Figure 2D)
