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The active form, 1,25-dihydroxyvitamin D3 (1,25[OH] 2 D 3 ), binds to the vitamin D receptor (VDR) expressed in endometrial stromal cells, leading to suppression of pro-inflammatory cytokine production (e.g., IL-8, TNF-), inhibition of NF-B signaling, and reduction in prostaglandin synthesis, which collectively dampen the chronic inflammatory milieu characteristic of endometriosis [20,21,22,23]

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Glucagon-like peptide-1 receptor agonist (GLP-1RA) and sodium-glucose cotransporter 2 inhibitor (SGLT2i) are currently recommended as first-line hypoglycaemic agents for patients with diabetes with established cardiovascular disease or multiple cardiovascular and renal risks [10]

PMID: 29741984

Despite these developments, significant obstacles remain, including tumor heterogeneity, complex resistance mechanisms, off-target effects, and limited predictive biomarkers

Direct supplementation of glutathione may seem like an easy solution to increase glutathione levels in the body, but studies have shown that this approach may not be effective