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The intranasal administration of GHK-Cu represents a novel approach aimed at overcoming the challenge of bypassing the blood-brain barrier, a common hurdle in traditional targeted neurotherapeutics (Ballabh et al., 2004

Notably, not only all humans, but also gorillas, chimps, orangutans, and some monkeys have this inborn genetic flaw, meaning that the loss of vitamin C biosynthesis must have occurred first in one of our primate ancestors

10.1016/j.sleep.2023.09.026 11 HasegawaE.MiyasakaA.SakuraiK.CherasseY.LiY.SakuraiT

It generates oxidative stress, damages cellular structures, and interferes with normal function

[PubMed: 2161738] 141

Transient Oxidative Stress Evokes Early Changes in the Functional Properties of Neonatal Rat Hypoglossal Motoneurons in Vitro
