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In addition to the catalytic function of PCBD1, the protein serves as a transcriptional co-activator for two transcription factors of the hepatocyte nuclear factor-1 family, HNF-1 (encoded by the HNF1A gene) and HNF-1 (encoded by the HNF1B gene)

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68 Of note, the BNIP3/NIX pathway was specifically up-regulated when mitochondrial oxidative stress was generated in the hypoxic environment to further induce mitophagy