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doi:10.1016/j.neuroscience.2009.08.028
By midlife, NAD+ can drop by 50%, exacerbated by inflammation and lifestyle.[14] Factors like poor diet, sedentary behavior, or chronic stress further deplete NAD+ by activating consuming enzymes, creating a vicious cycle
The hypothesis provides tenable predictions that may be tested in rigorously designed experiments in vitro and in vivo
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