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Overexpression of neutrophils and macrophages may result in cell and lung tissue damage as well as chronic inflammation, as shown in traditional cigarette smoking and, if unresolved, may lead to fibrosis, impaired lung function and structural changes in the airway (Cheng et al

This change was accompanied by a decrease in thyroid calcitonin expression

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NO-releasing agents, such as JS-K ( O 2 -(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate) 123 and PABA/NO ( O 2 -[2,4-dinitro-5-( N -methyl- N -4 carboxyphenylamino)phenyl] 1- N , N -dimethylamino)diazen-1-ium-1,2-diolate) 124 , are able to induce differentiation and cell death in a variety of cancer cells through GSH consumption, DNA synthesis inhibition and inhibition of enzymes involved in the defense against cell damage

N.ImE.StavridesP.PensalfiniA.et al (2022)

Practical Wisdom What Tuell and colleagues leave us with is more than data points it is a roadmap for resilience
