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This shift amplifies maladaptive responses under pathological conditions and reshapes both the metabolic and inflammatory landscape in neurodegenerative disease 81

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They showed that VitC was able to target common metabolic aberrancies by decreasing adenosine triphosphate (ATP) and glucose transporter 1 (GLUT-1) levels, as well as by dissipating the mitochondrial membrane potential, which could sensitize KRAS mutant CRC cells to current treatments such as chemotherapy

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Biol Rev Camb Philos Soc 2015;90(3):927-63

By comparison, the polyphenols which are large bulky higher molecular weight molecular structures typically exhibit bioavailability of around 1-8% [90]