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So, who is most at risk for developing this deficiency

Alterations of Vascular Thromboresistance The pioneer work of Harker et al (1976) suggests that endothelial cell injury associated with reduced platelet survival is involved in the initiation of vascular disorders induced by experimental hyperhomocysteinemia

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The term 'synergy' gets used when two compounds produce slightly better results together than alonebut true synergy means the combined effect exceeds the sum of individual effects, and that requires targeting rate-limiting steps in a shared pathway
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