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Lipid peroxidation induces ferroptosis Lipid peroxidation is an indicator of ferroptosis, and peroxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids in cell membranes is an important step of ferroptosis [29]

NRF2-addicted cancers are resistant to these cancer therapies due to their high intrinsic NRF2 activity

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Inflammatory cells are activated and inflammatory signaling pathways, specifically the NFB, MAPK, and the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways, are triggered by both infectious and noninfectious agents, as well as cellular damage (Mohammadi Zonouz et al

Epigenetic changes to DNA methylation for gene silencing have been proposed to be involved in MS (134, 135), ALS (136, 137), PD (138), and AD (139), so it may be relevant that toxic metals such as mercury can cause epigenetic alterations (140142)

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