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NICE guidance emphasises that treatment should not be delayed whilst awaiting confirmatory blood results if clinical suspicion is high
Mol Neurobiol 63:75

And because of such surface modification, the blood residence time of these PLGA NPs was extended, and consequently, the exposure of cargo to the BBB was enhanced too

Rather than acting within a single pathway, these compounds are studied for their roles across interconnected systems, where inflammatory signaling, tissue adaptation, and immune modulation form a continuous network
