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Beyond these fundamental roles, mitochondria are deeply involved in cancer cell survival, immune evasion, tumor progression, and the development of drug resistance, particularly under the hypoxic conditions of the tumor microenvironment (TME) 8,9

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Tumor necrosis factor- (TNF-) negatively affects the activity of mitochondrial complex I, which may result in mitochondrial dysfunction and cell death (Prajapati et al

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With a loading capacity of 97.6%, 99 g/mL Mito-TEMPO and 101 g/mL Se/LDH@PEG were used for therapeutic controls

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Die wichtigste Sicherheitsgrundlage sind die Phase-II-Studien zu RGN-259 (T4 als Augentropfen) und RGN-137 (T4 topisch bei chronischen Wunden), die ein gnstiges Sicherheitsprofil zeigten

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