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Long-term randomized trials are scarce, and dose-response across diverse populations needs refinement

Diabetes Prevention Program Research Group Impact of lifestyle intervention and metformin on health-related quality of life: the Diabetes Prevention Program randomized trial J Gen Intern Med 27 12: 1594-601

Interestingly, the weight loss and metabolic improvement observed in gastric bypass (RYGB) involve activation of the sympathetic tonus in the gut, which was associated with decreased CB1 and activation of WAT thermogenesis, a phenomenon known as browning that increases energy expenditure and resting metabolic rate (Ye et al., 2020)

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Regulation of skeletal muscle function by amino acids

doi: 10.1038/s41366-019-0430-0 154 GaoXLiuXXuJXueCXueYWangY
