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Deletion of NRF2 resulted in a notable decline in cell proliferation, demonstrated by decreased cell growth rates and colony formation capabilities (Fig

Because of this, it plays a central role in overall antioxidant defense, well beyond its cosmetic applications

Protein quantification was carried out using the MaxLFQ algorithm as implemented in the DIA-NN R package ( and the number of peptides quantified in each protein group was counted as implemented in the DiannReportGenerator package ( 71

P144, P145 Fatahi S

GSH is a cofactor and a synthetic substrate for GPX4, and it is required for the lipid repair function of GPX4 (Stockwell et al., 2017) and cystine/glutamate reverse transport system Xc- [or xCT/12 channel transmembrane protein transport protein carrier family 7 member 11 (SLC7A11) mediates the uptake of cystine to exchange the output of glutamate] was identified as the pivotal regulator for GSH synthesis (Hao et al., 2018)

Quantification of intracellular amino acids in batch cultures of Saccharomyces cerevisiae