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One pathway scientists are interested in targeting in type 1 diabetes is that which results from Smad7 signaling

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Since it is suggested that p53, p16, p21 are directly related to the induction of senescence in chondrocytes ( IL-6 and -8 , which however were not detectable due to the low expression level

Excitotoxicity is involved in many pathological conditions, such as cerebral ischemia, epilepsy, Parkinsons disease (PD), AD, and amyotrophic lateral sclerosis (ALS) (Lewerenz and Maher, 2015)
Their ALS progressed slower and they survived for much longer than untreated patients
