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Under adverse environmental conditions, excessive amounts of ROS are formed, which leads to oxidative stress

Glutathione Glutathione is one of the major antioxidants in our body

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Inflammatory cytokines secreted in the inflammatory area, such as granulocyte-macrophage colony stimulating factor (GM-CSF), TNF-, IL-1, and interferon, can activate HIF-1 to inhibit neutrophil apoptosis (62, 63)