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Abstract:Chronic hyperglycemia in diabetics causes microvascular damage through four mechanisms of biochemical changes, including activated protein kinase C (PKC) pathway, activated hexosamine pathway, increased polyol pathway, and increased advanced glycation end-products (AGEs), all of which will increase Reactive Oxygen Species (ROS) levels

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Summary Keywords radiation skin injury, radiodermatitis, fibrosis, pathway, mechanism, radiotherapy, computational biology, biomaterials Citation Wang Y, Chen S, Bao S, Yao L, Wen Z, Xu L, Chen X, Guo S, Pang H, Zhou Y and Zhou P (2024) Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis