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It is important to recognise that marketing claims linking B12 supplementation directly to weight loss are not supported by robust clinical evidence from UK or international health authorities

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In contrast, DFP treatment significantly decreased Fe 2+ levels in optic nerve tissue, downregulated TFR1 and Iba-1 expression, and inhibited iron deposition, ferroptosis, microglial activation, and astrocyte proliferation, thereby reducing myelin loss and optic nerve damage in MS mice (Rayatpour et al., 2022)

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So the typical pattern is a short loading phase of weekly shots to refill the tank, followed by a maintenance injection every few weeks to a month to keep levels steady